- Non-alcoholic Fatty Liver Disease and Hepatocellular Carcinoma
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Hyunwoo Oh, Dea Won Jun
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J Liver Cancer. 2017;17(2):117-125. Published online September 30, 2017
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DOI: https://doi.org/10.17998/jlc.17.2.117
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Abstract
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- Hepatocellular carcinoma (HCC) is one of the most common life-threatening cancers worldwide.
Recently, many patients with non-alcoholic fatty liver disease (NAFLD) and non-alcoholic
steatohepatitis (NASH) have progressed to HCC even in the absence of cirrhosis. As the
morbidity of metabolic syndrome increases, the proportion of HCC associated with NAFLD is
expected to increase gradually. A new mechanism for the development of HCC in NAFLD has
been identified; Diabetes mellitus, insulin resistance, obesity, lipotoxicity, gut dysbiosis are risk
factors. Inflammatory cytokines such as adipokines, leptin, tumor necrosis factor-α, interlukin-8,
nuclear factor-κB constitute dysplasia-carcinoma sequence. At the time of diagnosis, NAFLD/
NASH related HCC tend to progress to larger and in advanced tumor-node-metastasis stages
compared to viral hepatitis related HCC. But there are no guidelines for early detection of
NAFLD-related HCC. So, it is essential to study the screening program for the early detection of
NAFLD-related HCC and precise methods for NAFLD.
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